Police have confirmed that a person has died after a serious crash on State Highway 27 just north of Matamata this afternoon.

Police said they were called about a vehicle collision on SH27 at Ngarua, 18km north of Matamata, at 3.11pm.

"One person has died following what's believed to be a medical event on SH27, Ngarua, in Matamata-Piako district," a spokesman said.

"Police were called by the person, who was in a vehicle, at 3.11pm. Their family has been informed."

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St John Ambulance said three ambulances were dispatched but no one was transported to hospital, indicating that someone may have died at the scene.

The accident was believed to be at the intersection of SH27 and Given Rd. A woman is believed to have been given cardiopulmonary resuscitation but did not survive.