A truck driver has been flown to hospital after their vehicle crashed near Balclutha this morning.

A police spokeswoman said emergency services were called to the scene on Milton Highway, State Highway 1, shortly before 5am.

The truck was on its side, the spokeswoman said.

The Otago Rescue Helicopter Trust flew the driver to Dunedin Hospital but it wasn't clear how serious their injuries were.

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The Serious Crash Unit and Vehicle Safety Team was investigating and the road was initially closed at the intersection of Benhar Rd, with detours in place.

The road reopened shortly after 8am but the NZ Transport Agency said a stop-go control system was in place as well as a temporary speed restriction.

Drivers were warned of delays and asked to take care.