Waikato Police are searching for a car which was hit by a driver believed to be responsible for a serious crash.

The crash happened shortly before midnight on Friday, October 13 on State Highway 1 in Karapiro, near Hickey Rd and left two people with injuries. One patient was rushed to hospital in a serious condition.

Police were searching for the driver of a car clipped by the alleged offending vehicle before the main crash occurred.

The driver behind the wheel of the white or pearl coloured Honda Integra was believed to be a male Indian in his early 30's.

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He was described as being an average build, with clean cut hair and a beard.

His car would be missing the casing of the wing mirror.

Police said the driver isn't believed to be at fault in the crash, but officers were keen to speak to him.