The crash happened about the same time as a collision between two trucks at the intersection of SH3 and Lower Dudley Rd in Inglewood, south of New Plymouth.
One of the trucks involved in the crash was carrying transporter drums holding a hazardous chemical, a number of which have split on the road.
There were no injuries.
State Highway 3 was closed between Tawa St, Inglewood, and Durham Rd, Norfolk, while the spillages were cleaned up, with diversions in place.
Meanwhile, emergency services were attending to several oil spills on and near State Highway 3, Awahuri, between Palmerston North and Fielding.
Contractors were in the process of clearing up the area but motorists were urged to approach the area with caution; keep speeds down, increase following distances and buckle up.
Green Road and Awahuri Fielding Road were also affected by the spills.
The cause of spills is unclear at this stage.