After the owls have adorned Auckland, they will be sold at a charity auction.
"Owls are icons of storytelling, well known to represent wisdom, migration, diversity, learning and intelligence," said the foundation's chief executive, Robyn Kiddle.
"As with owls, every child and family who has walked the child cancer journey has their own unique story to tell.
"Each owl sculpture will share a unique and meaningful story.
"Every week, more than three children in New Zealand are diagnosed with cancer. At any given time, Child Cancer Foundation is assisting over 500 families nationwide, offering personalised, one-on-one support in hospital, at home and in the community."
The foundation hopes to raise $300,000.
A Big Hoot was held in Birmingham in the UK last year. The auction raised more than £500,000 ($877,815) for the Birmingham Children's Hospital charity.
• Businesses keen to take part can learn more at www.thebighoot.co.nz