"Two helicopters have reportedly been dispatched from Dunedin. The road is blocked and motorists are asked to avoid the area," a police spokeswoman said.
Fire & Emergency New Zealand southern shift manager Lyn Crosson said crews were at the scene.
"No one was trapped, so we didn't need to extricate anybody."
Nearby, emergency services are also at another crash at the intersection of State Highway 94 and Christie Rd.
"At around 4.50pm we received a report of a tractor and push bike that had collided."
One person with serious injuries has been flown to Dunedin Hospital in a helicopter.
The road was initially closed but has reopened.
"However due to the other crash just down the State Highway we would ask people to avoid the area still if possible," the spokeswoman said.