This included getting an off-duty police officer in Twizel to intercept the vehicle.
"But unfortunately while he was speaking to the driver he took off and crashed," said Gaskin. The driver survived with moderate injuries.
He said despite their best efforts, police were unable to prevent the tragedy.
"There was nothing more anyone could do. Everything was done to try to prevent it but unfortunately we were not dealing with a rational human being.
"Sometimes the best efforts we can do is just not enough."
He described the Mackenzie Country crash as one of the most serious he had seen for a number of years.
The crash, which closed the highway between Hayman and Tekapo Canal Rd, killed both men travelling in one car and left another in hospital with moderate injuries.
He said it had rocked the close-knit Twizel community robbing it of a man who was well regarded.
Police would like to hear from witnesses to the crash or from motorists who noticed a silver 2017 Toyota Highlander travelling north on SH8 before the crash.
Gaskin refused to say what had caused the crash but urged people not to drink before getting behind the wheel and to wear seatbelts.