A temporary speed limit of 50km/h was in place and the New Zealand Transport Agency advised motorists to delay their journeys or use alternative routes.
This latest incident followed a serious crash on State Highway 50 near Tikokino on Sunday where one person was trapped and three others were left injured.
Emergency services were called to the two-car crash near the Gwavas Rd intersection at about 5.40pm on Sunday. The Lowe Corporation Rescue Helicopter took a 54-year-old man with leg and head injuries to Hawke's Bay Hospital.
Rescue helicopter general manager Ian Wilmot said the man had been trapped in the car and was cut free by fire crews before being taken to hospital.
Two others with moderate injuries, and another with minor injuries, were taken to hospital by St John ambulance. A Hawke's Bay Hospital spokesperson said two children, a male and female aged 11-12, were in stable conditions as well as a female in her 40s.
The 54-year-old man was stable last night.
The road was closed while emergency services attended the scene but it reopened on Sunday night.
The Serious Crash Unit was investigating the circumstances surrounding the crash.