No names are being released as yet while police continue to make inquires into finding the next of kin and family members.
A passenger in the car also required hospital treatment, with minor injuries.
Keys said Rotorua police were very clear in their message to motorists.
"The faster you go the greater the chances of having a crash, and as a result the impacts are more severe."
Likewise, he said Bay of Plenty police were strong on enforcing the traffic legislation in relation to drivers failing to give way, and impulse decisions they might later regret.
"We urge all motorists to take care while driving and to have patience while driving."
Rotorua police are also seeking information from a motorist who may have been overtaken by the motorcyclist who was travelling south at the time and just before to the crash happened.
Anyone with information relevant to this investigation was asked to contact the police.