An occupant of the other car appeared to be uninjured but was taken to Hawke's bay hospital.
The serious crash unit was investigating.
Mr Marshall said police were trying to establish the identity of the male driver, as the vehicle was registered to a woman.
A detour is in place as a section of the expressway from Taradale to Kennedy roads remain closed.
Police are appealing for witnesses to the crash to come forward.
A statement released late tonight said the Serious Crash Unit was looking into the circumstances of the crash and had already spoken to a number of witnesses.
However, they were urging anyone else who saw the accident or the vehicles involved before the crash to come forward.
• Can you help? Call Hastings Police on: (06) 873 0500.