He acknowledged Christchurch Mayor Lianne Dalziel for her "fine leadership" of the city.
"Lianne feels people's issues, absolutely really personally. She believes in people, she feels their plight, she cares about them a great deal and you can see that in what she does. Christchurch needs you."
Key also took time to pay tribute to the work of Earthquake Recovery Minister Gerry Brownlee for his work after the quakes, saying that "history will remember you very kindly".
"When you're the person in charge of leading all of the recovery effort and dealing with the multitude of problems and challenges, then that is a very big ask.
"You need immensely broad shoulders and capability and stamina to do that. Most people probably couldn't put up with the pressure that creates but Gerry could. Gerry has done the most outstanding job for the people of Christchurch. If anyone deserves the keys to the city of Christchurch, it's Gerry."
The opening of the iSite will also help get tourists back to Kaikoura, which Key said would suffer a much-reduced summer season.
But he said the Government was working "very aggressively" to reopen State Highway 1.
After the formalities of the opening, he chatted with tourism and DoC staff.
He had the group laughing loudly, and posed for several photos and selfies.
It's understood that Key will also attend the opening of a community centre for residents of the Russley Village in Christchurch today.