Dotcom is fighting extradition to the United States where he faces allegations of internet piracy.
The Megaupload millionaire's court case was a topic of interest in the United States recently, when Hollywood lobbyists raised the case with Prime Minister John Key during his trip to Los Angeles.
Whilst in America this week, Ms Collins will visit Adult Drug Courts and hold discussions with the FBI and police officials on policies to combat drug offending.
The chats will include Commissioner Raymond Kelly of the New York Police Department.
"There is no doubt that alcohol and drugs are a problem for many communities in New Zealand, and where it results in crime it is important we take action," Ms Collins said.
She will also meet with experts on privacy and addressing the problems caused by cybercrime and cyber-bullying.
Ms Collins will also lay a wreath at the Vietnam War Memorial, visit Arlington National Cemetery in Washington, DC, and tour the 9/11 Memorial in New York.