Avondale senior station officer Chris Power said it appeared it was a gas explosion, possibly due to a leak.
He said the two people inside the house reported smelling gas at about 4am.
"And at approximately six o'clock this morning, one of the occupants got up and turned on a light and it appears that was the source of the ignition, which caused the explosion."
Power said investigators were at the scene and are yet to confirm the cause.
Several residents on the street said they all heard the powerful explosion and didn't know the pair who resided at the house.
Darshana Dabhoya lives across the road at number 56.
"We were just sleeping and I heard a big blast. I could hear a lady screaming really bad... really scared. And I could also see the flames and smoke coming from the house."
Priti Patel, who runs the Alpine Superette nearby and lives above it, said she heard "a big bang" and saw big flames from her window.