German Chancellor Angela Merkel tops the Forbes list for the eighth time.
US Federal Reserve chairwoman Janet Yellen is in second spot and philanthropist Melinda Gates is ranked third.
The Queen is ranked number 35.
Miss Clark's ranking has grown in recent years. She was number 50 three years ago and number 61 in 2009.
The top ten:
1. Angela MerkelGerman - Chancellor
2. Janet Yellen - Head of US Federal Reserve
3. Melinda Gates - Philanthropist
4. Dilma Rouseff - Brazil President
5. Christine Lagarde - IMF managing director
6. Hillary Clinton - Former politician
7. Mary Barra - General Motors CEO
8. Michelle Obama - US First Lady
9. Sheryl Sandberg - Facebook COO
10. Virginia Rometty - IBM CEO