Police officers attempted to pull the speeding vehicle over just as it went through a red light and struck an oncoming vehicle.
The driver then fled the scene and the injured occupants in the other vehicle were taken to Waikato Hospital.
Police are now looking for the driver of the offending vehicle after they were last seen running towards the nearby Pak'nSave on Mill St.
A Police dog unit was also sent to help locate the driver, but they were not found.
A St John spokesperson said they received a call just before 8pm and two ambulances, a manager and a rapid response vehicle attended the crash and transported one patient in a minor condition and the other in a moderate condition to Waikato Hospital. The two other patients were unable to be located.
A witness posted on social media that he ran outside after hearing the crash from his motel room. There was debris scattered across the road.
"There was a lot of aggro at the scene and police went off chasing someone," he posted.