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Having gout can increase the odds of dying from heart problems for men who already have risk factors for heart disease, a study suggests.
Researchers found that among 9100 middle-aged men at higher-than- average risk of heart disease, those with gout were more likely to die of a
heart attack or other cardiovascular cause over 17 years.
The findings should give men with gout extra incentive to have a doctor assess their cardiac risks, lead researcher Dr Eswar Krishnan said.
If they had modifiable risk factors - such as high cholesterol, high blood pressure or excess weight, - it would be important to get them under control, said Krishnan, an assistant professor at Stanford University School of Medicine.
He and his colleagues report the findings in the Archives of Internal Medicine.
Gout is a painful form of arthritis that causes the joints to periodically become swollen, red and hot.
It most often affects the big toe, but also strikes the feet, ankles, knees, hands and wrists.
Gout arises when uric acid crystals build up in the joints.
The body produces uric acid when it breaks down purines - substances found naturally in the body, but also in certain foods, such as "offal" meats, anchovies, mushrooms and some seafood, such as herring and mackerel.
Some research has linked high uric acid levels in the body to a higher risk of cardiovascular trouble.
Studies have also found that men with gout have higher-than-average rates of heart attack and angina - chest pain caused by insufficient blood flow to the heart.
The Stanford study involved 9105 men between the ages of 41 and 63 who were at elevated risk of heart disease because of smoking, high cholesterol and/or high blood pressure.
Those who also had gout were one-third more likely to die of coronary heart disease over 17 years, the researchers found.
They also had a higher risk of dying from any cardiovascular cause, such as stroke.
Controlling cardiovascular risk factors through diet, exercise, weight loss and medication is important for everyone, Krishnan noted.
But people with gout can reap the added benefit of improved joint symptoms, he said. Losing excess pounds and eating a healthful diet low in purines, for instance, could help cut uric acid levels and prevent gout attacks.
It's not entirely clear why gout is linked to heart disease death.
Excess uric acid in the body can create oxidative stress, a state that damages body cells and contributes to diseases, including the build-up of artery-clogging plaques.
Not everyone with high uric acid levels develops gout, the researchers note.
- REUTERS
