Dr Bram Smith, general manager of the joint CRI and university consortium KiwiNet, said the fund had proven a "key mechanism" for transforming clever science discoveries into commercial opportunities.
"PreSeed is about science driving business innovation, and the report shows that Government investment in this area is producing good economic returns for New Zealand."
PreSeed success stories include Cawthron Natural Compounds, Avalia Immunotherapies from the University of Victoria, ESR's STRmix, ArcActive - a spin out company from the University of Canterbury - and CropLogic from Plant and Food Research.
Others are the TOXINZ database, developed by the University of Otago, Electronic Navigation Ltdm which acquired WASSP intellectual property developed by Callaghan Innovation, and HaloIPT a spin out company from the University of Auckland.
Aduro Biopolymers and Ligar Polymers, commercialised by WaikatoLink, have also recently completed major deals.
The review was released jointly by KiwiNet, Return On Science and CDC Innovation.