Earlier, police said at least one other person was critically injured, and a further two had less serious injuries.
Diversions are in place at the scene, with traffic diverted through Mohaka township.
Police told Newstalk ZB it is understood some of the victims are locals.
"We don't know the identities or genders of the victims at this stage. We do know that some family members from some of the victims have shown up at the scene,'' said Inspector Paul Jermy.
The Police Serious Crash Team were on their way to the area, and the road was expected to be closed for several hours while the scene examination takes place.
Police say it is too early to speculate on the cause of the crash.
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