Development has been made in crash tests, larger cockpits with removable seats, better helmets to protect drivers and making the tracks safer.
The FIA governing body can also reduce the risk involved with race regulations and responsible drivers can follow the rules.
Former FIA president Max Mosley founded his own institute to research accidents under the leadership of Dr Sid Watkins.
"The progress in this respect is unbelievable," said Viviane Senna, Ayrton's sister.
That progress was seen first hand when the car of driver Robert Kubica was almost completely destroyed in a 2007 accident at the Canadian Grand Prix, only for the driver to emerge with only a concussion and a sprained ankle.
Aryton Senna (center) was the last fatality in Formula One. Photo / AP
The simple fact is a sport such as Formula One can never be completely safe.
In 2009, Felipe Massa suffered a severe eye injury when a metal spring broke off the car in front of him and struck him in the head.
"There is always the possibility that something strange can happen with serious consequences," said Vettel.
The battle for driver safety remains a core task even 20 years after the death of Ayrton Senna.
-AAP