Bore water is used for cooling systems and returned to source rather than using the city's water and sewerage systems.
Development of the site was to continue over the next 30 years.Four research themes for postgraduate study have been identified for the site, including health technologies, manufacturing and materials, novel technologies in manufacturing and sustainable energy systems.
Auckland University Dean of Engineering, Nic Smith, said the traditional image of the engineer as the man in the hard hat driving the bulldozer and who consumed significant amounts of the liquid once manufactured on the brewery site, no longer held true.
"We are undergoing a time of rapid transformation due to technology and engineering and science are at the forefront of that change," he said.
"The research and innovation that will be done on this campus will potentially touch the lives of every New Zealander."
University Vice-Chancellor Professor Stuart McCutcheon said the opening was a "milestone" for the university and provided an outstanding facility with a clear focus on excellent research.
"Newmarket Campus can be seen as a centre for world class research where our staff and postgraduate students will continue to develop and produce new technologies and science that will help take New Zealand into the future," he said.
"We are grateful for Auckland Council's support in facilitating the purchase of the former brewery site because the location means our relationships with industry and business, so vital to the future of business, the city and the university, are strengthened and enhanced."