Rain was forecast for tomorrow, and snow for Wednesday.
Milford Sound Lodge manager Japke Doodeman (correct) has said the closure meant the lodge was losing about 30 people a day.
"But considering all the boat companies and kayak companies that have buses coming in on a daily basis as well, it's quite a lot more than that."
There were 26 people staying at the lodge when the road was closed. Most had been flown out of the area.
Milford was "regularly" cut off, and the business was prepared when it happened, but this weekend's slip was "massive", she said.
"Over winter it does happen a bit more often, definitely towards the spring season because that's when the avalanche risk gets higher.