Police would also be targeting distracted drivers, drink driving and "other unsafe behaviour".
"We know people make mistakes on the road, but that shouldn't cost you or someone else life or limb.
"The speed you are travelling at is what determines whether you have time to react to those mistakes — or whether you become another crash statistic.
"People have a simple choice whether or not to speed, and there is irrefutable evidence that reducing your speed by even small amounts can make all the difference in whether you walk away from a crash or are carried away."
Mr Griffiths hoped for a repeat of Easter Weekend in 2012 and Queens Birthday Weekend last year, when there were no road deaths.
"It would be outstanding if we were able to repeat that result this weekend — and beyond."
Easter roads
• The Easter holiday period runs from 4pm the night before Good Friday and finishes at 6am the morning after Easter Monday.
• Last year three people were killed in crashes.
• Police will enforce a 4km/h speed threshold starting at 4pm today and running until 6am on Monday, April 28.