They were trying to clear the road with a couple of tow trucks, he said.
A helicopter had flown in and out of the scene.
A police spokesperson said the Marsden Point Road would remain closed for some time and the Serious Crash Unit remained at the scene.
Police have reopened SH1 in Oakleigh, which had diversions in place for a short time, following a separate crash where minor injuries were reported.
An unmarked police car had also collided with another vehicle, injuring two police officers and the driver of the other car.
The second crash had blocked State Highway 1 about 500m north of the Mangapai intersection.