Mr Wilkinson Smith said the Crown case was that only one of two people, the parents, could be the murderer.
Mr Mahomed and not his wife was charged with the murder, he said, largely on the transcripts of bugged conversations between the couple.
"That's the only thing on [Crown] evidence that says it's Mr Mahomed and not Mrs Mahomed."
The defence case would centre on flaws it says are in the police translation of the conversations, from Hindi into English. Mr Wilkinson Smith said there were "substantial mistakes" in the translation.
He called a Hindi expert from South Africa, Usha Desai, as a defence witness. She said she listened to one passage several times and heard Mr Mahomed say he was not guilty.
Police allege the Mahomeds coached their older daughter on how to answer questions about how Tahani was hurt.
The baby was malnourished when she died, weighing only 4kg.