Footage of the crash supplied to the Herald showed two cars each with crushed bonnets with debris strewn over the road.
Emergency services have closed Karaka Rd between Blackridge Rd and the Glenbrook roundabout.
Diversions are in place north of the crash at Karaka Rd and Great South Rd.
The Police Serious Crash Unit has been notified and will be attending.
“Police advise motorists to expect delays in the area this afternoon,” she said.
NZ Transport Agency told motorists to follow the directions of emergency services in the area, “and consider delaying your journey”.
A backlog from the crash was causing delays at the off-ramps at Great South Rd.