"If you work in this industrial zone you may also need to keep doors and windows closed tomorrow too.
"The main potential health effects are eye, skin or respiratory irritation," Sinclair said.
An Auckland Council spokesperson said the chemical had gone into a stormwater drain, and into the Manukau Harbour.
"If you have any further concerns, please contact Healthline on 0800 611 116 for advice," Sinclair said.
Auckland Council's Manager of Environmental Health Mervyn Chetty said warning signs were being put up in the area, and the Safeswim website was also telling people not to go into the water 5km from the spill – which covers Mangere Bridge, Taumanu East, Taumanu Central, Taumanu West and Onehunga.
Auckland Council staff, including environmental health and pollution experts, had been at the scene since it was reported.
They were working with Fire and Emergency NZ, and had been consulting with Auckland Regional Public Health, Auckland Council says.