The 37-year-old this week took over the reins from former Labour Party leader Andrew Little, who stepped down from the role on Tuesday morning.
A number of people have already submitted questions online - only one mentions children.
"What plans do u have to remove work obstacles for women with young kids? (sic)
"What's your position on drug reform?
"What do you think about the axing of $800k of Lifeline funding and the awarding [of] the contract to another provider?
"For some of us, simply staying alive is a struggle. What are your thoughts on mental health & suicide in NZ?''
The Q&A will start at 6.30pm via Ardern's official Facebook page.