Little said the family were sad about Buddy's apparent demise but the dog Harry, a border terrier, was taking it the hardest.
"The dog started crying last night. When Buddy was very unwell we had him in a dog cage and Harry saw the cage wasn't there yesterday and sat there howling. Then, later on, he saw Buddy's basket had gone and started howling there as well. Old Harry is missing Buddy."
He said the dog and cat were close.
"Well, you know, the cat tolerated the dog and the dog loved the cat."
It had been a rough year for Buddy, 10, who the Littles adopted from the SPCA in 2009.
Earlier this year, Little had to rush him to the vet for suspected poisoning after Buddy ate a rat.
Soon after he was diagnosed with liver cancer. Little said he had been told to expect the worst.
"So I got a chance to say my goodbyes."
He said Buddy had hoped to be part of the 2017 election campaign but it was not to be.