Nearly 40 per cent of the women said they were happy most of the time while 17 per cent said they were unhappy. After a decade of tracking the women, four per cent had died.
Scientists found the death rate among unhappy women was the same as those who were happy. The research was published in the medical journal Lancet.
"It's such a common belief that stress and unhappiness causes death and disease but it's actually the other way around," said Richard Peto, a professor at the University of Oxford who was one of the study's authors.
"People should focus on the real issues that shorten their lives, like smoking and obesity."
In an accompanying commentary, French scientists suggested that the results might not be the same in men, since "men and women probably define happiness differently".
AP