"I like the kind of engagement where you go to the website and you leave because you've found what you are looking for or you found something very interesting and you learned something.
"I think that's a much healthier engagement. Obviously, we want you to come frequently."
Twitter allows users to post short messages - no longer than 140 characters - for others to see online.
Among the first celebrities to use the site was Stephen Fry, who tweeted a picture of himself when he got stuck in a lift in 2009.
In his speech, Mr Stone admitted that when Twitter first launched many thought it would fail because they did not think it was useful. "Nobody thought it was a good idea," he said.
"And I distinctly remember my colleague Evan Williams saying, 'Well, neither is ice cream. Should we ban ice cream and all joy or can we have something that's just fun? What's wrong with that?'"
The speech has echoes of the infamous comments by tycoon Gerald Ratner in 1991, who effectively destroyed his cut-price jewellery empire when he said one of the firm's products was "total ***p".
- Daily Mail