His Twitter followers were quick to pick up on the obvious shade.
Most agreed with Morgan's sentiment that the couple has used the media to their own ends before complaining about the intrusion.
"Absolutely spot on !!" wrote one fan.
"Brilliant Piers, had a feeling you would take this stance," said another.
Some criticised the take, ribbing Morgan about his ongoing obsession with the duchess.
"My condolences to you. I know this is tearing you up inside. She now has two kids with him. It really is over between you two," one jabbed.
"I imagine that they frankly couldn't care less Mr Morgan," another said.
Morgan, who famously once counted the duchess as among a clutch of Hollywood friends, has a long history of attacking her and her husband.
His obsession was chronicled by a Twitter user who collated the vast number of stories written about the duchess.
Morgan once told an Irish television programme how his relationship with Meghan went south and the clip went viral when it was reshared earlier this year.
He said they had been following each other on Twitter and she had told him she was a fan of his. They began a friendship and, when Markle flew to the UK to see her friend Serena Williams play in Wimbledon, they agreed to meet at a pub.
"We had two hours in the pub, she had a couple of dirty martinis and pints – we got on brilliantly," he said in the interview.
"Then I put her in a cab, and it turns out it was the cab that took her to a party where she met Prince Harry."
"The next night they had a solo dinner and that was the last I ever heard from Meghan Markle. I never heard from her again – Meghan Markle ghosted me," he added.
However devastating it would have been for him to be rejected by the then Suits star, it's got to be nothing on losing your job because of 41,000 complaints following your statements on TV about her - which is precisely what happened to Morgan earlier this year, about five years after Markle "ghosted" him.
