Powers skilfully sketches the big picture but is equally capable writing about the private lives of his characters. Els' compulsions eventually wreck his marriage. He parts company with his closest collaborator and is distanced from his daughter, and Powers draws the reader into identifying with these domestic concerns.
The fierce intensity of youth and the dreary travails of age are conveyed with rare conviction, and Powers' writing has wit and elegance. On the run, Els is safest in crowds; "crowds of the young, who tended to look away, embarrassed, from anyone careless enough to have let himself get old".
A member of a musical appreciation group that he teaches confesses that "music was her North Korea - an unfathomable country that refused her a visa".
But for all his skill, Powers stumbles on that most difficult, perhaps impossible, task of converting music to words. His lengthy account of the Olivier Messiaen Quartet for the End of Time, like other passages, left me wandering to the CD rack and Els' fictitious compositions fail to come to life.
The narrative drive also falters as the novel progresses and the tension of his attempts to keep ahead of the hunters dissipates. There's an air about it of Powers not wanting anything in his notebooks to escape notice, from the sprinkling of tweets breaking up the text to the factoids about bacterial life.
But it's hard not to react with gratitude to a writer who tackles ideas and emotions with style and energy.
Orfeo by Richard Powers (Atlantic Books $36.99)