The model and presenter, who recently gave up alcohol as she and husband John Legend prepare to go through another round of IVF, was inundated with thousands of responses.
Twitter user Elizabeth Licata shared: "My 3yo got right in my face and screamed: 'You are over! Mommies are cancelled!"'
"Last week my kids (twins) came into the bathroom while I was in the shower, took the knob of the inside of the door and locked me in. Because why not," said another mother called Tanya.
One mother called Ande Wall shared her story: "Last week, my 20 month old offered me a bite of her food.
"As I went to accept it, she snatched it back and ate it. When I made a sad face she lifted her tiny pudgy fists to her eyes and slowly rotated them while saying 'wah wah wah' at me.
"I just wanted a damn bite of her Mac n cheese and she crushed me."
John and Chrissy welcomed baby Luna in April 2016, three years after marrying in Italy with the help of IVF - something which the pair have been open about.
They first met when Chrissy appeared in the music video for his single Stereo in 2007.