"Get ready for the green screens ... Twitter do your thing!" one social media user aptly predicted.
And the internet went wild. Some chose to take the opportunity to highlight some of the most frightening statistics during her husband's time in office, including the number of coronavirus cases by state.
Others simply had a laugh, mocking up the First Lady's dress with all kinds of alternative prints.
The best (by far) was the user who chose to superimpose Joe Biden's face over the dress.
No stranger to a fashion faux-pas, Melania has drawn criticism for her outfit choices in the past.
On the couple's official trip to Africa, Melania was mocked mercilessly for her endless wardrobe of khaki and neutrals.
The First Lady was slammed over a message emblazoned on the back of a Zara jacket in 2018, prompting the President to step in and justify her outfit choice.