Kardashian tries to ignore the comments as the pair, and two other nearby campaigners, are escorted away by security and continue yelling, "Shame on you!" as they leave.
More footage taken at the same event shows one man saying to Kardashian at the table, "It's wrong to wear fur, you need to stop wearing fur. It's horrible. You're a terrible person," and another says, "Can you make (the autograph) out to all the animals that have been tortured and killed for you to wear a fur coat?"
Kardashian and her sisters have been targeted for wearing fur in the past, and she was even attacked with flour at a red carpet event in 2012.
Meanwhile, true fans who queued for hours at the event were reportedly banned from taking their own cell phone snaps with her at the event.
Fans were banned from taking their own selfies at her selfie book signing event but New York Daily News reporter Reuven Blau managed to break the rules by snapping a quick shot with Kardashian.
"There were strict rules against engaging with Kardashian at all. Nothing would be allowed," he wrote.
"'No photos or inscriptions!' a beefy security guard repeatedly warned. I had other ideas.
"The plan was to secretly yank out my phone just as I finally made my way up to the desk where she was signing... My editor needed that shot - and my wife told me not to bother coming home if I muffed it... The resulting photo isn't perfect - I'm sort of looking in the wrong place and Kardashian is out of focus."
- WENN