Mrs Obama, a four-year veteran of the list, was named for the first time as part of a best-dressed couple, although President Barack Obama had been named on his own to the list once in 2009. Bruni-Sarkozy is another repeat recipient.
Justin Timberlake and Colin Firth were among those to make their first entries on the list, alongside actor Armie Hammer and Christine Lagarde, the chief of the International Monetary Fund.
Firth, who was in the spotlight earlier this year thanks to his success at the Academy Awards for his role in The King's Speech, certainly looked dapper on the red carpet, and it appears his suave look has earned him style icon status.
Timberlake's debut meanwhile, is likely thanks to his laidback approach to fashion and willingness to experiment with new looks.
In terms of Hollywood ladies, British stars Carey Mulligan and Tilda Swinton are both making their second appearance on the list.
Eccentric songstress Lady Gaga is representing the pop world, marking her second appearance in the compilation.
Another singer praised for her style is Janelle Monae, who often works a kooky-yet-casual aesthetic.
- AAP, AP