Understanding how age affected fertility was becoming increasingly important as couples delayed childbearing toward later stages of their lives.
Photo / 123RF
Understanding how age affected fertility was becoming increasingly important as couples delayed childbearing toward later stages of their lives.
Photo / 123RF
Conflicting evidence about the extent to which men's semen quality declines with age - likely lowering their fertility - is being cleared up by a new review of data from 90 previous studies from around the world.
Researchers from the new University of Otago found consistent age-related declines in semenvolume and sperm performance and increases in malformed and DNA-damaged sperm. Semen quality is regarded as a proxy for how fertile a male is.
Lead author Dr Sheri Johnson said understanding how age affected fertility was becoming increasingly important as couples delayed childbearing toward later stages of their lives.
"While female age is well known to have negative effects on fertility, reproductive success and the health of offspring, the influence of male age on a couple's fertility has been largely neglected.
"The effects of declining semen traits with increasing male age have largely been ignored due to inconsistencies in the literature, but our work now suggests that male age affects a variety of traits.
"It is well recognised that reduced sperm performance can affect pregnancy success, but it is less well known that the quality of the sperm, particularly DNA quality, could affect the development and health of the offspring," Dr Johnson said.
Dr Johnson and her team have reviewed 90 individual studies, spanning around 94,000 volunteers/patients from more than 30 countries. Their Marsden-funded study appears in the international journal, Ageing Research Reviews.
"Our study made no attempt to estimate the rate of decline, but some well-controlled clinic-based studies have observed consistent declines with increasing age, whereas others project declines after age 35 for some traits and after age 40 for others."
