She did not have any children of her own but is survived by a number of nieces and nephews, including Prince Carlos of Bourbon-Parma, Duke of Parma and Piacenza, Princess Margarita and Prince Jaime.
The royal death comes as Spain registers a record number of coronavirus deaths in a day. And reports state the Spanish army is now being handed emergency powers to transfer bodies because undertakers are unable to cope.
News of the princess' death follows the revelation last week that the UK's Prince Charles, 71, tested positive for the virus, but only has a "mild" case.