About 5000 babies are born pre-term in New Zealand every year. Photo / 123RF
About 5000 babies are born pre-term in New Zealand every year. Photo / 123RF
Kiwi researchers are pioneering a new blood test for pregnant women that could potentially prevent babies being born too early.
Preterm birth remains the leading cause of child death in almost all high-income and middle-income countries - and globally, more than one in 10 babies are born before 37 weeks'gestation.
Here in New Zealand, the rate is around eight per cent - and 14.6 per cent among Maori - and equates to some 5000 babies each year.
While the vast majority survive, they can carry a greater risk of problems with growth, learning, and adult diseases, such as obesity and diabetes, than babies born at term.
Efforts to tackle the risk have hit one major problem: about 60 per cent of these births happened without any warning, and often in women with no history of it.
There was still no way of reliably predicting whether a woman will go into labour prematurely - yet that might be about to change.
A team of researchers at the University of Auckland-based Liggins Institute and the University's Faculty of Medical and Health Sciences have identified a unique molecular "fingerprint" in blood taken from women at 20 weeks of pregnancy who all went on to have their babies early, or at between 28 and 32 weeks.
The fingerprint was absent from blood taken from women at the same stage in pregnancy who went on to deliver at term.
In a new two-year programme, supported with a Royal Society Te Apārangi fellowship, Liggins' Professor Mark Vickers aimed to develop and validate the test in groups of women here, and in Australia and Ireland.
The potential biomarker revealed in the pilot study was derived from analysing what's called micro-RNA, or miRNA.
MiRNAs are small non-coding RNA molecules that play key roles in the regulation of gene expression.
They're also known to be involved in the development of, and protection from, a range of diseases.
Recent studies in this fast-emerging field have highlighted the potential for miRNAs as biomarkers for osteoporosis, cancer and the pregnancy complication pre-eclampsia.
The research team lead by Vickers used state-of-the-art digital technology called NanoString, designed to count the number of individual miRNA molecules present in a maternal blood sample.
Much more sensitive and faster than other available methods, it demonstrated recent rapid advances in technology and medicine.
"If this test proves effective, it could potentially lead to much better outcomes for the babies and their mothers, both in the short and long term," Vickers said.
"It could enable the targeting of existing and future therapies to delay or even prevent preterm birth.
"The platform could also be used to detect other pregnancy complications, such as gestational diabetes."
Andrew Taberner is developing an instrument to measure heart-cell performance. Photo / Supplied
Meanwhile, another University of Auckland project supported Royal Society Te Apārangi fellowship will use 3D "bio-printing" to gain fresh insights into human heart cells.
Associate Professor Andrew Taberner has begun developing a new instrument for measuring the performance of contracting heart cells.
The heart comprises billions of cardiac muscle cells which co-ordinate their contractions to pump blood around the body.
But one cardiac muscle cell is not necessarily like another; their behaviour varies throughout the heart, and can deteriorate when the heart is diseased.
A better understanding of the performance of heart cells in different contexts could provide opportunities to develop new treatments for diseases affecting the heart.
Yet the process of making mechanical measurements of isolated heart cells was currently painstaking and slow.
"We urgently need to develop new high-throughput technologies and tools to speed up the measurement process," Taberner said.
Over two years, his team will develop a cutting-edge device with which to study living, contracting cells harvested from the heart.
This will include 3-D bioprinting of isolated cells in a format that allows rapid testing of their properties.
This project will involve the development of new bioprinting technologies, image processing methods, and new miniature cell-testing devices.
The research team plan to bring these together in a system compatible with tools currently used in biological research and in the pharmaceutical industry.
This device could prove useful for many other types of cells: in food science, it could even be used to develop new forms of lab-grown meat.
