Anger during the 48 hours preceding symptom onset was self-assessed by the 313 patients' reporting from on the scale on which 1 was "calm", and 7 was "enraged, out of control, throwing objects, hurting yourself or others". The threshold of acute anger in the study was defined as level 5 - "very angry, body tense, maybe fists clenched, ready to burst".
Seven of the confirmed heart attack patients (2.2 per cent) had reached an anger of at least level 5 within the two-hours before their symptoms began.
Based on the subjects' usual patterns, the relative risk of onset of heart attack symptoms occurring within two hours of reaching anger level 5 or above was calculated as 8.5 times greater than that associated with normal levels on the anger scale.
The trigger events for the 313 patients included road rage, work stress and family rows.
One of the researchers, Dr Thomas Buckley, said the absolute risk of any one anger episode triggering a heart attack was low, but the study showed the danger was real.
The increased risk of heart attack following intense anger or anxiety probably resulted from increased heart rate and blood pressure, tightening of blood vessels and increased clotting - physiological changes that were all associated with triggering of heart attacks.