Rada Mihalcea and colleagues at the University of Michigan studied video clips of high profile court cases. They discovered that, contrary to expectations, liars made more direct eye contact with their interrogators than did truth-tellers. They also tended to scowl or grimace significantly more often, and they used hand gestures more frequently than those who told the truth. When answering questions, liars punctuated their speech more often with vocal fillers such as "um" and "ah".
James Pennebaker at the University of Texas was interested in spotting the difference between truth-telling and lies in written material. He found that liars use more negative emotional words - for example, "hate" and "sad". They also use fewer exclusionary words such as "but", "except" and "nor", words that mark the distinction between what the author did and did not do.
Pennebaker also found that liars have a tendency to distance themselves from what they're saying by avoiding the use of the word "I". Instead, they describe situations using the third person - "he" or "she".
Of course, liars - as well as those who are looking out for them - have access to this information, so those who intend to deceive can teach themselves to behave as if they're telling the truth. Nevertheless, it's difficult to hold on to a plausible lie at the same time as remembering how to appear and how to present evidence convincingly.
Therefore, the key is to look for multiple cues, both in body language as well as in the content and structure of the explanations given.
Linda Blair is a clinical psychologist, author of The Key To Calm.