Animals initially exposed to dry roasted peanut proteins subsequently developed a far stronger immune reaction to peanuts.
Dr Amin Moghaddam, from Oxford University, said: "Our results in mice suggest that dry roasted peanuts may be more likely to lead to peanut allergy than raw peanuts: The dry roasting causes a chemical modification of peanut proteins that appears to activate the immune system against future exposure to peanuts.
"Allergies in people are driven by multiple factors including family genetic background and exposure to environmental triggers. In the case of peanut allergy, we think we may have discovered an environmental trigger in the way that peanuts are processed by high-temperature roasting."
Professor Quentin Sattentau, who led the team from Oxford University's Dunn School of Pathology, said: "This is the first time, to our knowledge, that a potential trigger for peanut allergy has been directly shown."
But he said the research was at an early stage and it would be premature to avoid roasted peanuts or their products.
- PAA