The hip hop icon was the first musician in history to have his first five albums reach number one on the US Billboard chart.
The legendary rapper had been comatose in a New York hospital since last week, after a drug overdose led to a heart attack.
Yesterday, it was reported the rapper had undergone a brain function test and it had shown no improvements.
DMX was hospitalised five days ago and at the time, his prognosis was "not good" and he remained in a coma.
Tributes to the artist have been pouring in on social media after news of his death.
LeBron James, Missy Elliot and Chance the Rapper are just a few to share their respects.
The Grammy-nominated rapper shot to stardom in the early 1990s, with his debut album It's Dark and Hell Is Hot in 1998, which received critical acclaim and commercial success, selling 251,000 copies within its first week of release.
The rapper was most well known for his iconic tunes X Gon Give It To Ya and Ruff Ryder's Anthem.
He topped the charts numerous times, in the US and around the world, over the course of his career.