Dr Anthony Fauci, the nation's leading infectious disease expert, dismissed the claim as misinformation during an interview on Tuesday on CNN.
"There's no evidence that it happens, nor is there any mechanistic reason to imagine that it would happen," he said.
Throughout the year, the White House has struggled to counteract resistance to getting a shot, particularly among younger and more Republican demographics. The administration has pointed in particular to false or misleading information about the safety and efficacy of the vaccines as a driver of that hesitance. It has referenced a study by the Centre for Countering Digital Hate, a nonprofit that studies extremism, that linked a dozen accounts to spreading the majority of vaccine disinformation on Facebook.
The administration has sought out new ways to refute disinformation and reach young vaccine skeptics, earlier this year inviting teen pop star Olivia Rodrigo to the White House to show her support for the shot.