It's the latest salvo in the US culture war that Mr Trump seems to relish. Across social media platforms this week, Americans hotly debated whether Bee — whose feminist style comedy often criticises sexism — was justified in using a misogynistic expletive to criticise Ivanka Trump.
Trump supporters noted that the term used by Bee would result in immediate pushback had it been aimed at a female Democratic official, such as Rep. Nancy Pelosi.
Mr Trump himself has repeatedly drawn fire for his sexist language and sexual boasting. A 2005 Access Hollywood video featured audio of Mr Trump bragging about how he grabs women's genitalia and gets away with it.
On the tape, the president talks about forcing himself on women, kissing them and groping them. Mr Trump eventually apologised for his comments.
The Samantha Bee incident also underscored the unprecedented role Ivanka Trump plays at the White House. While the children of presidents are often shielded from public jokes by comedians because of their age and because they aren't White House employees, Ivanka Trump has taken an active policy role as an adult in her father's White House.
A close presidential adviser, she has promoted the administration's tax overhaul and led a US delegation at the Winter Olympics in South Korea.
Bee has apologised to Ivanka Trump and her viewers for using the obscenity. Her network, TBS, also said it was "our mistake, too," in allowing the language on Bee's show, Full Frontal. Her show is taped and not aired live.
Barr has separately apologised for her remarks.
