The news of the model's death - which was confirmed by Variety - comes amid the Palme D'Or winning film making its way around the film festival circuit, including Cannes, Toronto and New York.
In the Ruben Ostlund-helmed satire, Dean starred as Yaya who was invited on a yacht vacation that goes wrong alongside Woody Harrelson and Harris Dickinson.
Dean's other projects include 'Death Race 3: Inferno', 'Blood in the Water', 'Don't Sleep' and 'Porthole'. Through her modelling work, she graced the covers of the South African editions of GQ and Elle.
Her fiance Luke Volker, a model, reacted to the tragic news of her passing on Instagram, saying he "couldn't be more proud" of her and performance in 'Triangle of Sadness'.
Playwright Jeremy O'Harris tweeted: "This is absolutely devastating. Charlbi Dean was such an exciting performer to me after seeing her in Triangle of Sadness.
"Her work had a vulnerability and intellect a lesser actor would have denied the character. A true talent and sending love to her family."