Oprah, who hosted 4,561 episodes of the talk show, added that when Beyonce asked her if she'd been OK she simply told the singer, "Girl, you're Beyonce!"
The TV icon also told the crowd at the panel that the success of the Oprah show was no accident.
"One of the reasons why the Oprah show was number one all those years is because we had intended for it to be so," she said.
The host would meet with the producers before every episode and would tell them, "Don't just give me a show idea, have an intention behind the show", she said.
"I have to be able to find my own intention within the show, some stream of truth, so that I will not be sitting there being phony."