The performance was tipped as the 27-year-old's big comeback and was her first TV performance in two years.
Dressed in a floor-length black long-sleeved gown, Gomez belted out the song, which includes the lyrics: "You promised me the world and I fell for it. I put you first and you adored it. Set fires in my forest, and you let it burn. Sang off-key in my chorus. 'Cause it wasn't yours."
Gomez was supported by her musician friends Taylor Swift and Halsey at the ceremony.