According to People magazine, the couple spentthe weekend perfecting finishing touches at The Breakers, where they arrived on Thursday night to start welcoming the close to 400 guests who will attend today's ceremony.
The Breakers, a hotel in the Italian renaissance style at West Palm Beach on the east coast of Florida, was a strategic choice by the Modern Family actress who wanted to make it equally easy for guests to arrive from South America, the United States and Europe.
This Friday the couple supervised the final details with famed floral artist Jeff Leatham, artistic director of the Four Seasons Hotel George V in Paris, who is in charge of decorating the wedding celebration.
The Barranquilla native, 43, and Manganiello, 38, known for the True Blood series, got engaged in Hawaii last December, six months after falling for each other.
This will be Manganiello's first marriage, the Colombian's second after first tying the knot with Jose Luis Gonzalez, with whom she has a son, Manolo, 23.
It will be Manolo who will hand the bride Vergara over to groom Manganiello, also known for the parts he played in the movies Magic Mike in 2012 and Magic Mike XXL in 2015.
The couple has asked that their guests, instead of giving them presents, make donations to charitable causes including the St Jude Children's Research Hospital, which treats children with cancer.
