"It's a huge year, so don't forget to vote... for the Academy Awards when that comes around," he joked.
The night of nights saw a mix of high-profile celebrities attending, including Sigourney Weaver, Andy Garcia, Bradley Cooper, Matt Damon and Kristen Wiig.
During the event, Ridley Scott was honoured, with Weaver and Wiig, along with several other celebrities, taking the stage to acknowledge the acclaimed producer and director.
The black tie affair was held in the International Ballroom of the Beverly Hills Hilton Hotel.
This isn't the first time Russell has tried his hand at comedy using crude humour.
In April this year, the Oscar winner made his first appearance as host on comedy show Saturday Night Live.
One of his first gags he made during a very brief monologue was when he stated he was known for his comedic roles... the star then flicking to a clip of him impaling a fighter to death in Gladiator.
"Cracks me up every time I see that," he chuckled. "I used two swords! I could've used one. And I was wearing a dress."
The Kiwi featured in four sketches on the night, with three of them featuring vagina gags, and none of them drawing much laughter.
